Endocrine Abstracts

Introduction: Klinefelter`s syndrome is a chromosomal abnormality characterised by presence of one or more extra X chromosome(s). The commonest karyotype is 47 XXY. We report a case of craniopharyngioma in a patient with Klinefelter`s syndrome.Case report: A 72-year-old single male presented with three-month history of decreased left eye visual acuity with associated frontal headache and lethargy. His past medical history included osteoporosis and Klinef...

IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that caused a global pandemic in 2020. The virus has infected more than 100 million people worldwide and the pandemic is still spreading. It can affect practically all organs. Data on the impact of SARSCoV-2 on the thyroid gland are very scarce. Two patients with Graves’ disease (GD) and COVID-19 have been recently published(1). We present a case GD occur...

Purpose: To determine the prevalence of nodular thyroid disease, autoimmune thyroid disease, goiter and primary thyroid dysfunction in patients with active Cushing’s disease.Patients and methods: Nineteen patients with active Cushing’s disease (17 female, 2 male, mean age 43.16±3.55 years) and forty, age and gender matched healthy volunteers who served as the control group (34 female, 6 male, mean age 47.28±2.31 years) were included i...

Introduction: Central Serous Retinopathy (CSR) is a condition characterized by the accumulation of sub-retinal fluid at the posterior pole of the fundus, creating a circumscribed area of serous retinal detachment. It is associated with increased levels of endogenous or exogenous glucocorticoids and has been described in patients with Cushing’s syndrome (CS).Here we report on two cases we recently managed in our unit, with central serous retinopathy ...

Objective: Familial combined hyperlipidemia (FCH) is the most common familial hyperlipidemia with a high risk of the early atherosclerosis. The aim of this study was to compare levels of s-ICAM-1 and s-VCAM-1 in asymptomatic members of FCH families with healthy controls and to find out relation between s-ICAM-1, respective s-VCAM-1, and risk factors accompanying FCH. We also investigate association between adhesion molecules and intima-media thickness of common carotid artery ...

Case history: Our patient is a 64 year old lady who had bilateral adrenalectomy in 1978 for Cushing”s disease. This was followed by radiotherapy in late 1978. To get further reduction of the ACTH producing pituitary adenoma she had transsphenoidal surgery in 1979 and then transfrontal craniotomy in 1982. This was followed by further radiotherapy in 1985. It left her with panhypopituitarism and she was on full hormone replacement. She presented to our hospital in late 2008...

25-years-old lady presented to gastroenterologist with recurrent bouts of vomiting associated with abdominal pains, fatigue, muscle aches and dark tan. Initial biochemical profile and upper GI endoscopy were normal. On examination she had dark pigmentation of the palms well hydrated and haemodynamically stable. No family history of autoimmune conditions. She had traumatic laceration of the liver as a child, otherwise no significant past medical history.A...

Introduction: Hypopituitarism due to Sheehan′s syndrome is a rare complication and its diagnosis is often overlooked. The vast majority of people with hypothyroidism have primary hypothyroidism, often due to Hashimoto’s thyroiditis. Coexistence of hypopituitarism and primary hypothyroidism, may accelerate clinical manifestations, mainly those associated with hypothyroidism. Hashimoto′s Thyroiditis with concomitant hypopituitarism is rare but has been described...

History: A 52-year-old woman was referred by her GP for colonoscopy in view of 7 months” history of unexplained weight loss of nearly 2.5 stones, constipation and recently detected normocytic anaemia. Her past medical history was unremarkable except for bronchial asthma that was managed with albuterol. However, on the day of the scheduled colonoscopy, she was noted to be hypotensive (BP- 63/38 mm Hg, heart rate 93 bpm) and was hence admitted for fluid resuscitation. Follo...

Background: Early diagnosis of Cushing’s syndrome and initiation of effective treatment are essential to limit long-term morbidity and early mortality. However, diagnosis is often delayed due to the non-specificity of symptoms, or because symptoms are not recognised by physicians, leading to more complex treatment needs and a worsening of patient quality of life. A survey was conducted to better understand the patient experience of Cushing’s syndrome and the true b...